keratinocyte growth factor造句

• In contrast, FGF7 ( keratinocyte growth factor, KGF ) binds only to FGFR2b ( KGFR ).
• This particular family member is a high-affinity receptor for acidic, basic and / or keratinocyte growth factor, depending on the isoform.
• Human Genome Sciences has discovered a wound-healing factor, known as keratinocyte growth factor-2, which is in now in clinical trials for its ability to heal venous ulcers.
• The others are keratinocyte growth factor 2, which stimulates growth of the skin and mucosal tissue, and myeloproliferation inhibitory factor 1, to be used for protecting the bone marrow cells in patients receiving chemotherapy.
• One, for example, known as keratinocyte growth factor 2, is a protein that stimulates the cells of the skin and inner body linings to heal wounds, and is being tested on patients with nonhealing ulcers.
• TGF-?1, tumor necrosis factor-?, interleukin-1, nerve growth factor, and keratinocyte growth factor are factors that have been shown to regulate TN-C . Other extracellular matrix components such as matrix metalloproteins and integrins are also frequently co-expressed with TN-C.
• During embryogenesis, the epidermis splits into two layers : the periderm ( which is lost ) and the TGF-a, and through paracrine signal FGF7 aka keratinocyte growth factor ( KGF ) produced by the dermis below the basal cells.
• FGF7 and FGF10 ( also known as Keratinocyte Growth Factors KGF and KGF2, respectively ) stimulate the repair of injured skin and mucosal tissues by stimulating the proliferation, migration and differentiation of epithelial cells, and they have direct chemotactic effects on tissue remodeling.
• Chronic wounds also differ in makeup from acute wounds in that their levels of proteolytic enzymes such as elastase . and matrix metalloproteinases ( MMPs ) are higher, while their concentrations of growth factors such as Platelet-derived growth factor and Keratinocyte Growth Factor are lower.
• Major contributions include a ) the development of strategies to enhance post-transplant immune reconstitution such as Interleukin-7, Keratinocyte Growth Factor, Sex Steroid Blockade, Interleukin-22 ( IL-22 ), and adoptive cell therapy with precursor T cells and b ) novel insights in the pathophysiology of graft-versus-host disease ( GVHD ) such as the role of T cell cytolytic pathways, intestinal homing molecules, donor-derived neovascularization, and more recently, intestinal microflora